ABSTRACT
Small cell carcinoma of the ovary, hypercalcemic type [SCCOHT] is a very rare and lethal tumor, mostly affecting young women, with aggressive clinical course. It has a worse prognosis in younger women and most of them died within two years of diagnosis. We are reporting a unique case of SCCOHT in a 35 years old, nulliparous lady with primary infertility in which symptomatic hypercalcemia was a presenting feature of her cancer. She was completely healthy before third cycle of IVF. Within two months of her third IVF cycle, she developed SCCOHT with a very rapid and aggressive course of disease and fatal outcome. Patient died within one month of her first symptom presentation [3 months after IVF cycle]
ABSTRACT
The objectives of this study were to find out the frequency and the pattern of carcinoma in situ occurring in association with different types of breast cancers. This study was conducted in the Department of Clinical Oncology and the Department of Pathology, King Edward Medical University/ Mayo Hospital, Lahore on breast cancer patients diagnosed between 1[st] January 2001 and 31[st] December 2005. The age, menopausal status, histopathological type, grade, and presence or absence of carcinoma in situ were recorded. Histopathological features were recorded according to WHO system. Grade was recorded only when it was assigned according to the Elston-Ellis modification of Scarff-Bloom-Richardson grading system. A total of 1230 histopathologically documented invasive and non-invasive breast cancers patients were included in the study. DCIS alone was seen in seven patients [00.57%] and LCIS alone in two patients [00.16%]. Invasive ductal carcinoma was seen in 998 patients [81.14%] and invasive lobular carcinoma in 96 patients [07.80%]. Majority of breast cancers were grade II whereas grade I seen in 23.90% patients only. Areas of carcinoma in situ in different types of invasive cancers were seen in 328 [26.86%] patients. Majority of these patients were below 50 years of age. DCIS was present in 246 of 998 patients [24.65%] of invasive ductal carcinoma [NOS]. Comedo pattern was seen in 154 of 290 [53.10%] of DCIS. LCIS was present in 38 of 96 patients [39.58%] of invasive lobular carcinoma. Carcinoma in situ of breast is a turely diagnosed disease entity in our setting. It is seen mostly in association with invasive carcinoma of breast cancer. Ductal carcinoma in situ with comedo pattern is most frequent
Subject(s)
Humans , Female , Breast Neoplasms/pathology , Carcinoma in Situ/diagnosis , Carcinoma in Situ/epidemiology , Early Detection of CancerABSTRACT
To evaluate the spectrum of childhood liver diseases. Design: A department-based retrospective study. Place and Duration of Study: It was carried out at the department of Pathology, Children's Hospital and the Institute of Child Health, Lahore, over a period of two years [October 1998 to October 2000]. Subjects and The histopathological data of total 50 percutaneous needle biopsies, wedge biopsies and partial hepatectomy specimens of both the sexes between 1 month - 16 years age were collected and compared with the findings reported from centers in other parts of the country. The commonest cause of hepatomegaly was hepatic inflammatory disorder in 43 cases [29%] followed by biliary atresia in 40 cases [27%]. Other causes of hepatomegaly were hepatic neoplasia 11 cases [7.3%], cirrhosis 10 cases [7%], glycogen storage disease 10 cases [7%] and fatty change in 8 cases [5.3%]. Hepatic diseases are quite common in paediatric population in Pakistan and percutaneous needle liver biopsy is an important and helpful diagnostic procedure in undiagnosed cases of hepatomegaly